Construction of CdSe Quantum Dots &ldquo;Switch&rdquo; and Its Application in Pharmaceutical Analysis

YANG Kun; CHEN Lin-qing; ZHAO Hui-kai; WANG Yi-lin; QIN Ze-hua

doi:10.3788/fgxb20153603.0312

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Construction of CdSe Quantum Dots “Switch” and Its Application in Pharmaceutical Analysis

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- Construction of CdSe Quantum Dots “Switch” and Its Application in Pharmaceutical Analysis
- Chinese Journal of Luminescence Vol. 36, Issue 3, Pages: 312-316(2015)
- 作者机构：
  
  1. 广西大学化学化工学院广西石化资源加工及过程强化技术重点实验室,广西南宁,530004
  2. 广西大学材料科学与工程学院,广西南宁,530004
- 作者简介：
- 基金信息：
- DOI：10.3788/fgxb20153603.0312
  CLC： O482.31
- Received：27 November 2014，
  
  Revised：06 January 2015，
  
  Published Online：12 January 2015，
  
  Published：03 March 2015
- 稿件说明：
移动端阅览
杨昆, 陈林情, 赵慧凯等. CdSe量子点“开关”的构建及其在药物分析中的应用[J]. 发光学报, 2015,36(3): 312-316

YANG Kun, CHEN Lin-qing, ZHAO Hui-kai etc. Construction of CdSe Quantum Dots “Switch” and Its Application in Pharmaceutical Analysis[J]. Chinese Journal of Luminescence, 2015,36(3): 312-316
杨昆, 陈林情, 赵慧凯等. CdSe量子点“开关”的构建及其在药物分析中的应用[J]. 发光学报, 2015,36(3): 312-316 DOI： 10.3788/fgxb20153603.0312.

YANG Kun, CHEN Lin-qing, ZHAO Hui-kai etc. Construction of CdSe Quantum Dots “Switch” and Its Application in Pharmaceutical Analysis[J]. Chinese Journal of Luminescence, 2015,36(3): 312-316 DOI： 10.3788/fgxb20153603.0312.

摘要

以CdCl

2.5H

SeO

和NaBH

为反应物

制备巯基丁二酸稳定的CdSe量子点。在合成的量子点中加入一定浓度的铜离子

铜离子结合于量子点表面而使其荧光猝灭。在猝灭后的体系中加入青霉胺

由于青霉胺能使结合于量子点表面的铜离子释放出来而使量子点的荧光恢复。据此

建立了一种CdSe量子点"开关"测定青霉胺的新方法。在选定的实验条件下

方法的线性范围为1~72 g/mL

检出限为0.031 g/mL。应用于实际样品中青霉胺的测定

结果令人满意。

Abstract

CdSe quantum dots were prepared by the reaction of CdCl

2.5H

SeO

and NaBH

in water and in the presence of mercaptosuccinic acid as stabilizer. The fluorescence of quantum dots can be significantly quenched by copper ions. However

in the presence of penicillamine

copper ions were released from the quantum dots and thus restored the fluorescence of quantum dots. A new type of fluorescence turn-on assay for detection of penicillamine using quantum dots/copper ion ensemble is developed. Under the selected conditions

the response was linearly proportional to the concentration of penicillamine from 1 to 72 g/mL

the limit of detection was 0.031 g/mL. The developed method has been successfully applied to the detection of penicillamine in real samples with satisfactory results.

关键词

Keywords

references

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Construction of CdSe Quantum Dots “Switch” and Its Application in Pharmaceutical Analysis

DOI：10.3788/fgxb20153603.0312

摘要

Abstract

关键词

Keywords

references