Surface Modification of NaYF4:Yb3+, Er3+ Luminescent Upconversion Nanocrystals and Biological Effects

SONG Kai; DU Chuang; ZHAO Jun-wei; KONG Xiang-gui

doi:10.3788/fgxb20123311.1215

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Surface Modification of NaYF₄:Yb³⁺, Er³⁺ Luminescent Upconversion Nanocrystals and Biological Effects

更新时间：2020-08-12

- Surface Modification of NaYF₄:Yb³⁺, Er³⁺ Luminescent Upconversion Nanocrystals and Biological Effects
- Chinese Journal of Luminescence Vol. 33, Issue 11, Pages: 1215-1218(2012)
- 作者机构：
  
  1. 发光学与应用国家重点实验室中国科学院长春光学精密机械与物理研究所,吉林长春,130033
  2. 长春师范学院生命科学学院,吉林长春,130032
- 作者简介：
- 基金信息：
- DOI：10.3788/fgxb20123311.1215
  CLC： O433.4
- Received：17 August 2012，
  
  Revised：24 September 2012，
  
  Published：10 November 2012
- 稿件说明：
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宋凯, 杜创, 赵军伟, 孔祥贵. NaYF4:Yb3+, Er3+发光上转换纳米晶的表面修饰及其生物效应[J]. 发光学报, 2012,(11): 1215-1218

SONG Kai, DU Chuang, ZHAO Jun-wei, KONG Xiang-gui. Surface Modification of NaYF4:Yb3+, Er3+ Luminescent Upconversion Nanocrystals and Biological Effects[J]. Chinese Journal of Luminescence, 2012,(11): 1215-1218
宋凯, 杜创, 赵军伟, 孔祥贵. NaYF4:Yb3+, Er3+发光上转换纳米晶的表面修饰及其生物效应[J]. 发光学报, 2012,(11): 1215-1218 DOI： 10.3788/fgxb20123311.1215.

SONG Kai, DU Chuang, ZHAO Jun-wei, KONG Xiang-gui. Surface Modification of NaYF4:Yb3+, Er3+ Luminescent Upconversion Nanocrystals and Biological Effects[J]. Chinese Journal of Luminescence, 2012,(11): 1215-1218 DOI： 10.3788/fgxb20123311.1215.

摘要

不理想的发光上转换纳米晶(UCNPs)表面效应成为其生物标记的主要障碍。本文合成了表面带有氨基功能基团的水溶性NaYF

:Yb

UCNPs

并通过共价偶联的方式将聚乙二醇(PEG)分子修饰到其表面。光谱测试表明纳米晶的发光性质基本没有变化

扫描电镜结果说明修饰的PEG分子在一定程度上减少了纳米晶的聚集。最后

细胞毒性实验证明这种修饰后的上转换纳米晶具有良好的生物相容性。

Abstract

Undesirable surface effect of luminescent upconversion nanoparticles (UCNPs) is a major obstacle to the biomarker. In this work

we synthesized the water-soluble NaYF

:Yb

UCNPs with amino functional groups and polyethylene glycol (PEG) molecules modified by covalent coupling of the way to the surface of UCNPs. The spectral characterization showed that the luminescent properties of UCNPs unchanged. Scanning electron microscopy results indicate that modification of PEG molecules distinctly reduce the aggregation of UCNPs. The cell toxicity experiments show that this modification on the UCNPs has good biocompatibility.

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references

Rao J H, Dragulescu-Andrasi A, Yao H Q. Fluorescence imaging in vivo recent advances [J]. Current Opinion in Biotechnology, 2007, 18(1):17-25.

Choy G, Choyke P, Libutti S K. Current advances in molecular imaging: noninvasive in vivo bioluminescent and fluorescent optical imaging in cancer research [J]. Mol. Imaging, 2003, 2(4):303-312.

de Chermont Q L, Chaneac C, Seguin J, et al. Nanoprobes with near-infrared persistent luminescence for in vivo imaging [J]. Proc. Natl. Acad. Sci. USA,2007, 104(22):9266-9271.

Cai W, Shin D W, Chen K, et al. Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects [J]. Nano Lett.,2006, 6(4):669-676.

Suyver J F, Grimm J, van Veen M K, et al. Upconversion spectroscopy and properties of NaYF4 doped with Er3+, Tm3+ and/or Yb3+ [J]. J. Lumin., 2006, 117(1):1-12.

Krämer K W, Biner D, Frei G, et al. Hexagonal sodium yttrium fluoride based green and blue emitting upconversion phosphors [J]. Chem. Mater.,2004, 16(7):1244-1251.

Lim S F, Riehn R, Ryu W S, et al. In vivo and scanning electron microscopy imaging of up-converting nanophosphors in caenorhabditis elegans [J]. Nano Lett., 2006, 6(2):169-174.

Zhao J W, Kong X G. AEP-assisted hydrothermal synthesis and upconversion luminescence of NaYF4:Yb3+, Er3+ nanocrystals [J]. Chin. J. Lumin.(发光学报),2011, 32(7):675-679 (in Chinese).

Masao K, Daisuke M, Yu S, et al. Design of poly(ethylene glycol)/streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling [J]. Langmuir,2008, 24(16):8864-8870.

Wolfgang E, Gary C, Aruna S, et al. PEGylated gold nanoparticles conjugated to monoclonal F19 antibodies as targeted labeling agents for human pancreatic carcinoma tissue [J]. ACS Nano,2008, 2(11):2263-2272.

Lu Z H, Chen H, He C F, et al. Synthesis of water soluble upconversion NaYF4:Yb3+,Er3+nanoparticals using polyvinylpyrrolidone as surfactant and their biological compatibility [J]. Chin. J. Lumin.(发光学报),2011, 32(10):993-997 (in Chinese).

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