Preparation and Characterization of Liposome Coated Hydrophobic CdSe/ZnS Core-shell QDs

SHAO Tai-li; LI Ping; ZHAO Zhi-gang; SONG Xue-fei; ZHU Chang-qing

doi:10.3788/fgxb20123311.1187

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Preparation and Characterization of Liposome Coated Hydrophobic CdSe/ZnS Core-shell QDs

更新时间：2020-08-12

- Preparation and Characterization of Liposome Coated Hydrophobic CdSe/ZnS Core-shell QDs
- Chinese Journal of Luminescence Vol. 33, Issue 11, Pages: 1187-1191(2012)
- 作者机构：
  
  1. 皖南医学院药学系,安徽芜湖,241002
  2. 安徽师范大学化学与材料学院,安徽芜湖,241002
- 作者简介：
- 基金信息：
- DOI：10.3788/fgxb20123311.1187
  CLC： O482.3
- Received：22 May 2012，
  
  Revised：17 August 2012，
  
  Published：10 November 2012
- 稿件说明：
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邵太丽, 李萍, 赵志刚, 宋雪飞, 朱昌青. 脂溶性CdSe/ZnS量子点脂质体复合物的制备及表征[J]. 发光学报, 2012,(11): 1187-1191

SHAO Tai-li, LI Ping, ZHAO Zhi-gang, SONG Xue-fei, ZHU Chang-qing. Preparation and Characterization of Liposome Coated Hydrophobic CdSe/ZnS Core-shell QDs[J]. Chinese Journal of Luminescence, 2012,(11): 1187-1191
邵太丽, 李萍, 赵志刚, 宋雪飞, 朱昌青. 脂溶性CdSe/ZnS量子点脂质体复合物的制备及表征[J]. 发光学报, 2012,(11): 1187-1191 DOI： 10.3788/fgxb20123311.1187.

SHAO Tai-li, LI Ping, ZHAO Zhi-gang, SONG Xue-fei, ZHU Chang-qing. Preparation and Characterization of Liposome Coated Hydrophobic CdSe/ZnS Core-shell QDs[J]. Chinese Journal of Luminescence, 2012,(11): 1187-1191 DOI： 10.3788/fgxb20123311.1187.

摘要

在油相中成功合成了脂溶性CdSe/ZnS核壳量子点纳米粒

粒径平均为4.5 nm

量子产率达29%

发射波长为540 nm。通过薄膜分散法

以蛋黄卵磷脂、胆固醇为膜材

将脂溶性的CdSe/ZnS核壳量子点包覆于脂质体磷脂双分子层中

由于磷脂分子的两亲性

使得脂溶性的CdSe/ZnS核壳量子点同时又具有亲水性。通过透射电镜对脂质体形态进行了表征

倒置荧光显微镜证实了发光CdSe/ZnS核壳量子点成功包埋于脂质体双分子层中

包裹的发光CdSe/ZnS核壳量子点具有更稳定的发光及抗光漂白性质。

Abstract

In the organic phase

hydrophobic CdSe/ZnS core-shell quantum dots (QDs) were synthesized successfully using a free-phosphine and non-injecction method. The transmission electron microscopy (TEM) shows CdSe/ZnS core-shell nanocrstals with an average diameter of 4.5 nm. The fluo- rescence quantum yield of the QDs

calibrated with fluorescein using a 470 nm laser

was found to be 29%

which was greatly increased compared with bare CdSe QDs

indicating strong photoluminescence. The maximum emission wavelength of QDs was 540 nm at excitation of 410 nm. Through the thin-film evaporation method

using the L-α-phosphatidylcholine and Cholesterol

the hydrophobic CdSe/ZnS core-shell QDs were successfully embedded in the two-layer of liposome. As the amphipathy of phospholipid molecules

rendering the luminescent hydrophobic CdSe/ZnS core-shell QDs hydrophilia

CdSe/ZnS core-shell QDs can be transferred in water without extra surface combining reagents. The morphology of liposome was characterized by TEM using negatively stained method

the process of CdSe/ZnS core-shell QDs embedded in the phospholipid two-layer was confirmed by inverted fluorescent microscopy under the UV light. The result indicates that CdSe/ZnS core-shell QDs embedded in the phospholipid two-layer have more photostability and more resistant photobleaching.

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Keywords

references

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