Interaction of Rare Earth with Bovine Serum Albumin

FENG Xiao-qiang; FU Guo-qing; LI Xiao-fang; YANG Sheng; SU Zhong-xing

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Interaction of Rare Earth with Bovine Serum Albumin

paper | 更新时间：2020-08-12

- Interaction of Rare Earth with Bovine Serum Albumin
- Chinese Journal of Luminescence Vol. 32, Issue 2, Pages: 205-209(2011)
- 作者机构：
  
  1. 天水师范学院生命科学与化学学院,甘肃天水,741001
  2. 天水市中医医院,甘肃天水,741001
  3. 兰州大学化学化工学院,甘肃兰州,730030
- 作者简介：
- 基金信息：
- DOI：
  CLC： O657.3;O482.31
- Received：04 June 2010，
  
  Revised：10 August 2010，
  
  Published Online：22 February 2011，
  
  Published：22 February 2011
- 稿件说明：
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冯小强, 伏国庆, 李小芳, 杨声, 苏中兴. 稀土La(Ⅲ)、Nd(Ⅲ)与牛血清白蛋白的相互作用[J]. 发光学报, 2011,32(2): 205-209

FENG Xiao-qiang, FU Guo-qing, LI Xiao-fang, YANG Sheng, SU Zhong-xing. Interaction of Rare Earth with Bovine Serum Albumin[J]. Chinese Journal of Luminescence, 2011,32(2): 205-209
冯小强, 伏国庆, 李小芳, 杨声, 苏中兴. 稀土La(Ⅲ)、Nd(Ⅲ)与牛血清白蛋白的相互作用[J]. 发光学报, 2011,32(2): 205-209 DOI：

FENG Xiao-qiang, FU Guo-qing, LI Xiao-fang, YANG Sheng, SU Zhong-xing. Interaction of Rare Earth with Bovine Serum Albumin[J]. Chinese Journal of Luminescence, 2011,32(2): 205-209 DOI：

摘要

采用紫外吸收、荧光光谱和红外光谱

研究了稀土离子La(Ⅲ)和Nd(Ⅲ)与牛血清白蛋白(BSA)的相互作用。结果表明: La(Ⅲ)和Nd (Ⅲ)离子能配位诱导BSA

使其分子中色氨酸和酪氨酸芳杂环疏水基团外露

在280 nm处的吸收增强而表现出增色效应和较小的蓝移。La(Ⅲ)和Nd(Ⅲ)可以有规律地猝灭BSA的内源荧光

其猝灭机理是稀土离子与BSA形成复合物的静态猝灭。在20 ℃下

La(Ⅲ)和Nd (Ⅲ)与BSA的结合常数

分别为8.1210

和3.8510

。

Abstract

The interaction of rare earth La (Ⅲ) and Nd (Ⅲ) with BSA were studied by ultraviolet spectrum

fluorescence spectrum and IR spectrum. The results showed that the ultraviolet absorption intensity of BSA increases with the concentration of rare earth. Rare earth can strongly quench the fluorescence of BSA which is the static quenching. The binding constant (

) of La (Ⅲ) or Nd (Ⅲ) with BSA at room temperature are 8.1210

and 3.8510

respectively.

关键词

Keywords

references

Wang Dongmei, Liu Qingyun, Jian Jiangzhuang, et al. Synthesis and optical properties of transparent resins containing rare earth compounds [J]. Chin. J. Lumin. (发光学报), 2009, 30 (4):427-435 (in Chinese).[2] Cui Haixia, Chen Jianmin, Zhou Huidi. Synthesis and fluorescence properties of rare earth complex with a new diamidel ligand [J]. Chin. J. Lumin. (发光学报), 2009, 30 (4):457-462 (in Chinese).[3] Deng Ruwen, Zhang Zhongsheng. Rare earth medicine and pharmacy property [J]. Chin. Rare Earth (稀土), 1987,(3):36-47 (in Chinese).[4] Sugio S, Kashima A, Mochizuki S, et al. Crystal structure of human serum albumin at 2.5  resolution [J]. Protein Eng., 1999, 12 (6):439-446.[5] Liu Baosheng, Xue Chunli, Wang jing, et al. Studies on the interaction between ciprofloxacin and ofloxacin in presence of bovine serum albumin by spectroscopic methods [J]. Chin. J. Lumin. (发光学报), 2010, 31 (2):285-290.[6] Tang Bo, He Xiwen, Shen Hanxi. Analysis of synchronous and derivative synchronous fluorescence spectra of phenol and dihydroxybenzene [J]. Spectroscopy and Spectral Analysis (光谱学与光谱分析), 1998, 18 (1):21-26 (in Chinese).[7] Huang Bo, Zou Guolin, Yang Tianming. Studies on the interaction between adriamycin and bovine serum albumin [J]. Acta Chimica Sinica (化学学报), 2002, 60 (10):1867-1871 (in Chinese).[8] Xuan Guangshan, Wu Xiaonan, Li Yuping. Fluorescence study on the interaction of acetylsalicylic acid and bovine serum albumin [J]. Chin. J. Spectroscopy Laboratory (光谱实验室), 2005, 22 (7):861-864 (in Chinese).[9] Xie Mengxia, Xu Xiaoyun, Wang Yingdian. Spectroscopic investigation of the interaction between 2,3-dihydro- 4',5,7-trihydroxyflavone and human serum albumin [J]. Acta Chimica Sinica (化学学报), 2005, 63 (22):2055-2062 (in Chinese).[10] Chen Guozhen, HuangXianzhi, Zheng Zhuxing. Fluorescence Analytic Technique[M]. Beijing: Science Press, 1990:122.[11] Li Guizhi, Liu Yongming, Guo Xinyun, et al. Study on the interaction between bovine serum albumins and topotecan hydrochloride or irinotecan hydrochloride [J]. Acta Chimica Sinica (化学学报), 2006, 64 (7):679-685 (in Chinese).

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